ATXN1

Across TCGA pan-cancer cohorts, ATXN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATXN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ATXN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATXN1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ATXN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATXN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.618	<.001	11	view →
HNSC	All	III,IV	+0.604	<.001	10	view →
KICH	Female	All	−0.958	<.001	9	view →
THCA	All	II,III,IV	−0.528	<.001	8	view →
LIHC	All	All	+0.514	<.001	8	view →
BRCA	All	II,III,IV	+0.333	<.001	6	view →
CHOL	All	All	+1.121	<.001	5	view →
BLCA	All	All	−0.662	.011	5	view →
UCEC	All	All	−1.010	<.001	4	view →
COAD	Female	All	−0.382	.026	2	view →
READ	Female	All	−0.734	.043	1	view →
LUSC	Male	All	−0.234	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATXN1–KIRC

Open the KIRC breakdown →