ATXN1

Across TCGA pan-cancer cohorts, ATXN1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ATXN1 data layer compared with 28 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ATXN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ATXN1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM, LSCC, and CCRCC are the cancer types where ATXN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.665	0.366	.007	6	view →
LSCC	OS	Median	All	0.767	1.000	.015	2	view →
CCRCC	DFS	Median	III,IV	0.465	0.731	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ATXN1–GBM (OS)

Open the GBM breakdown →