ATXN1

Across TCGA patient cohorts, ATXN1 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATXN1-associated genes across cancer lineages are ATM, mTOR_pS2448, and Cyclin-B1. Each is linked with ATXN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATXN1-to-partner and partner-to-ATXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ATXN1-low versus ATXN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN1→partner) and Y-score (partner→ATXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.548	-4.379	<.001	<.001	3	4
UCEC	mTOR_pS2448 →	-0.116	-1.273	.005	.007	3	3
UCEC	Cyclin-B1 →	+0.735	+2.044	<.001	<.001	3	3
COAD	Cyclin-E2 →	+0.225	+2.832	.049	.034	3	2
SKCM	eEF2 →	+0.352	+2.000	.017	.031	3	2
SKCM	PCNA →	+0.304	+2.321	<.001	.033	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

ATM by ATXN1 expression — UCEC

Explore this box plot interactively →