ATXN1

Across TCGA cell cohorts, ATXN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,991 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ATXN1-associated GO terms across cancer lineages are Endosomal transport, Regulation of protein localization to membrane, and Regulation of intracellular transport. Each is linked with ATXN1 in more than 11 cancer types. Because this analysis shows association rather than direction, both ATXN1-to-partner and partner-to-ATXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by ATXN1-low versus ATXN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN1→partner) and Y-score (partner→ATXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endosomal transport →	+0.051	+1.308	<.001	<.001	3	12
BONE	Regulation of protein localization to membrane →	+0.082	+1.562	<.001	<.001	3	11
SKIN	Regulation of intracellular transport →	+0.070	+0.775	<.001	<.001	3	11
BONE	Positive regulation of intracellular transport →	+0.084	+1.543	<.001	<.001	3	11
BONE	Golgi to plasma membrane protein transport →	+0.106	+1.461	<.001	<.001	3	11
SOFT_TISSUE	Positive regulation of viral process →	+0.079	+2.157	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,991 associations by consensus.

Endosomal transport by ATXN1 expression — BONE

Explore this box plot interactively →