ATXN1

Across TCGA cell cohorts, ATXN1 mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATXN1-associated genes across cancer lineages are TPH1, PRIMPOL, and SEPHS1. Each is linked with ATXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATXN1-to-partner and partner-to-ATXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPH1 grouped by ATXN1-low versus ATXN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATXN1→partner) and Y-score (partner→ATXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TPH1 →	+0.226	+3.192	.004	.007	3	2
LARGE_INTESTINE	PRIMPOL →	+0.593	+3.364	.003	.002	3	2
LARGE_INTESTINE	SEPHS1 →	+0.599	+3.169	.004	.009	3	2
BLOOD_Leukemia	NR3C2 →	+0.335	+3.378	.009	.005	3	2
BLOOD_Leukemia	ZNF232 →	+1.316	+3.199	.001	.007	3	2
LUNG_NSCLC_LUAD	FZD8 →	+0.941	+3.358	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

TPH1 by ATXN1 expression — LARGE_INTESTINE

Explore this box plot interactively →