ATRN

Across TCGA patient cohorts, ATRN mutation is significantly associated with the RNA expression of many other genes, with 3,901 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATRN-associated genes across cancer lineages are KCTD9, RN7SKP107, and YWHAQP1. Each is linked with ATRN in more than 2 cancer types. Because this analysis shows association rather than direction, both ATRN-to-partner and partner-to-ATRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by ATRN-low versus ATRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRN→partner) and Y-score (partner→ATRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.626	+2.343	<.001	<.001	3	3
HNSC	RN7SKP107 →	+0.067	+4.547	<.001	.004	3	3
READ	YWHAQP1 →	+0.135	+6.257	<.001	.001	3	3
UCEC	RPL23AP82 →	+0.418	+3.413	<.001	<.001	3	3
UCEC	RNU6-333P →	+0.089	+2.244	.001	.009	3	3
UCEC	HPF1 →	+0.405	+2.098	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,901 associations by consensus.

KCTD9 by ATRN expression — UCEC

Explore this box plot interactively →