ATRN

Across TCGA pan-cancer cohorts, ATRN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ATRN data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ATRN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATRN expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

MESO, KIRC, and BLCA are the cancer types where ATRN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.288	0.522	.003	73	view →
KIRC	OS	Tertile	All	0.780	0.562	<.001	63	view →
BLCA	DFS	Quartile	All	0.090	0.599	<.001	62	view →
UVM	OS	Median	III,IV	0.653	0.920	.002	53	view →
READ	DFS	Quartile	III,IV	0.978	0.530	.001	33	view →
UCS	OS	Tertile	II,III,IV	0.620	0.242	.012	30	view →
COAD	DFS	Tertile	All	0.699	0.838	.010	21	view →
STAD	OS	Median	All	0.383	0.684	.001	18	view →
PRAD	DFS	Quartile	All	0.962	0.848	.001	18	view →
SKCM	OS	Tertile	IV	0.283	0.851	.010	12	view →
KICH	OS	Quartile	II,III,IV	0.535	0.911	.035	11	view →
SARC	OS	Quartile	All	0.439	0.820	.002	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ATRN–MESO (DFS)

Open the MESO breakdown →