ATRN

Across TCGA patient cohorts, ATRN mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATRN-associated genes across cancer lineages are VEGFR2, ERK2, and MEK1. Each is linked with ATRN in more than 1 cancer types. Because this analysis shows association rather than direction, both ATRN-to-partner and partner-to-ATRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by ATRN-low versus ATRN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRN→partner) and Y-score (partner→ATRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	VEGFR2 →	+0.286	+2.321	.015	.033	3	2
UCEC	ERK2 →	+0.159	+1.807	.007	.024	3	2
UCEC	MEK1 →	+0.523	+2.169	<.001	<.001	3	2
UCEC	MSH2 →	-0.227	-1.880	.001	.014	3	2
UCEC	mTOR_pS2448 →	-0.126	-1.565	.006	.017	3	2
UCEC	Myosin-IIa_pS1943 →	+0.145	+1.428	.024	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

VEGFR2 by ATRN expression — SKCM

Explore this box plot interactively →