ATRN

Across TCGA cell cohorts, ATRN mutation is significantly associated with the RNA expression of many other genes, with 269 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATRN-associated genes across cancer lineages are PPIL4, ZUP1, and PBK. Each is linked with ATRN in more than 1 cancer types. Because this analysis shows association rather than direction, both ATRN-to-partner and partner-to-ATRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIL4 grouped by ATRN-low versus ATRN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRN→partner) and Y-score (partner→ATRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPIL4 →	+0.512	+3.364	.007	.002	3	2
LARGE_INTESTINE	ZUP1 →	+0.699	+3.364	<.001	.002	3	2
LARGE_INTESTINE	PBK →	+0.889	+3.234	.003	.004	3	2
BLOOD_Myeloma	BPIFA2 →	+0.020	+4.807	<.001	.006	3	1
LUNG_SCLC	PRAMEF27 →	+0.015	+4.643	<.001	.004	3	1
BLOOD_Lymphoma	DEFB129 →	+0.018	+3.925	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 269 associations by consensus.

PPIL4 by ATRN expression — LARGE_INTESTINE

Explore this box plot interactively →