ATRN

Across TCGA cell cohorts, ATRN mutation is significantly associated with the mutation status of many other genes, with 4,460 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATRN-associated genes across cancer lineages are PREX2, ANKRD12, and CCDC88A. Each is linked with ATRN in more than 4 cancer types. Because this analysis shows association rather than direction, both ATRN-to-partner and partner-to-ATRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX2 grouped by ATRN-low versus ATRN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRN→partner) and Y-score (partner→ATRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PREX2 →	+2.169	+2.502	.006	.006	1	5
BLOOD_Leukemia	ANKRD12 →	+2.285	+3.364	.006	.006	1	5
BLOOD_Leukemia	CCDC88A →	+3.870	+4.050	.002	.002	1	5
OVARY	PARD3B →	+3.345	+3.345	.007	.007	1	5
BLOOD_Leukemia	PXDN →	+2.584	+3.640	.003	.003	1	5
LARGE_INTESTINE	EMSY →	+3.321	+2.807	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,460 associations by consensus.

PREX2 by ATRN expression — BLOOD_Lymphoma

Explore this box plot interactively →