ATRIP

Across TCGA cell cohorts, ATRIP mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATRIP-associated genes across cancer lineages are MAGEB5, UNC5D, and TUB. Each is linked with ATRIP in more than 1 cancer types. Because this analysis shows association rather than direction, both ATRIP-to-partner and partner-to-ATRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by ATRIP-low versus ATRIP-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATRIP→partner) and Y-score (partner→ATRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	UNC5D →	+0.049	+3.354	<.001	.002	3	1
LARGE_INTESTINE	TUB →	+1.215	+3.304	.003	.008	3	1
LARGE_INTESTINE	GKN1 →	+0.043	+2.925	<.001	.007	3	1
LARGE_INTESTINE	GLIS1 →	+0.311	+3.669	<.001	.008	3	1
LARGE_INTESTINE	WSCD2 →	+0.113	+3.660	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MAGEB5 by ATRIP expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →