ATR

Across TCGA patient cohorts, ATR protein abundance is significantly associated with the RNA expression of many other genes, with 9,552 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ATR-associated genes across cancer lineages are KIF14, TOP2A, and CEP55. Each is linked with ATR in more than 4 cancer types. Because this analysis shows association rather than direction, both ATR-to-partner and partner-to-ATR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ATR versus KIF14 in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATR→partner) and Y-score (partner→ATR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF14 →	+0.790	+0.267	.007	<.001	3	5
BRCA	TOP2A →	+1.220	+0.271	<.001	<.001	3	5
LSCC	CEP55 →	+1.068	+0.329	<.001	<.001	3	5
BRCA	NUF2 →	+1.177	+0.299	<.001	<.001	3	5
BRCA	SKA1 →	+0.929	+0.257	.001	.002	3	5
LSCC	GMPS →	+0.764	+0.315	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,552 associations by consensus.

ATR vs KIF14 — BRCA

Explore this scatter interactively →