ATP9A

Across TCGA patient cohorts, ATP9A mutation is significantly associated with the RNA expression of many other genes, with 4,815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP9A-associated genes across cancer lineages are KIF18A, CENPU, and MELK. Each is linked with ATP9A in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP9A-to-partner and partner-to-ATP9A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF18A grouped by ATP9A-low versus ATP9A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP9A→partner) and Y-score (partner→ATP9A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF18A →	+0.483	+2.606	<.001	<.001	3	5
UCEC	CENPU →	+0.689	+2.566	<.001	<.001	3	5
UCEC	MELK →	+0.511	+2.513	.002	<.001	3	5
BRCA	IGHD4-4 →	+1.298	+3.875	<.001	.006	3	4
COAD	PTMAP9 →	+0.890	+2.249	<.001	.006	3	4
SKCM	ARHGAP11A →	+0.506	+2.100	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

KIF18A by ATP9A expression — UCEC

Explore this box plot interactively →