ATP8B4

Across TCGA pan-cancer cohorts, ATP8B4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ATP8B4 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ATP8B4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ATP8B4 expression acts as an unfavorable survival marker, although some lineages such as CESC and STAD show a favorable association.

CESC, STAD, and LUAD are the cancer types where ATP8B4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	1.000	0.553	.018	18	view →
STAD	DFS	Median	II,III,IV	0.795	0.357	.020	18	view →
LUAD	OS	Median	All	0.693	0.816	.012	15	view →
KIRP	OS	Median	All	0.270	0.904	<.001	12	view →
UCEC	OS	Median	IV	0.232	0.608	.006	6	view →
SKCM	OS	Median	II,III,IV	0.915	0.829	.020	4	view →
LGG	OS	Median	All	0.548	0.801	.012	3	view →
HNSC	DFS	Median	All	0.342	0.629	.038	3	view →
BLCA	OS	Median	IV	0.198	0.471	.046	3	view →
BRCA	OS	Median	All	0.842	0.963	.036	2	view →
COAD	OS	Median	II,III,IV	0.258	0.672	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ATP8B4–CESC (DFS)

Open the CESC breakdown →