ATP8B2

Across TCGA patient cohorts, ATP8B2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B2-associated genes across cancer lineages are Caspase-7-cleavedD198, p53, and PCNA. Each is linked with ATP8B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP8B2-to-partner and partner-to-ATP8B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP8B2-low versus ATP8B2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B2→partner) and Y-score (partner→ATP8B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.634	+1.915	.027	.009	3	3
UCEC	p53 →	-0.275	-2.000	.022	.029	3	2
UCEC	PCNA →	+0.206	+1.415	.002	.010	3	2
UCEC	Shc_pY317 →	-0.093	-1.247	.049	.041	3	2
UCEC	TFRC →	+0.463	+2.415	.004	.002	3	2
UCEC	Chk2_pT68 →	-0.171	-2.781	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by ATP8B2 expression — COAD

Explore this box plot interactively →