ATP8B2

Across TCGA pan-cancer cohorts, ATP8B2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ATP8B2 data layer compared with 9 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP8B2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP8B2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

UVM, BLCA, and LUAD are the cancer types where ATP8B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.323	0.616	<.001	117	view →
BLCA	OS	Median	All	0.523	0.697	<.001	113	view →
LUAD	DFS	Median	II,III,IV	0.643	0.432	<.001	79	view →
ACC	DFS	Quartile	All	0.125	0.760	<.001	49	view →
LGG	DFS	Median	All	0.289	0.492	<.001	45	view →
HNSC	DFS	Tertile	IV	0.655	0.459	.001	45	view →
PAAD	OS	Median	All	0.701	0.480	.004	41	view →
LUSC	DFS	Median	III,IV	0.539	0.789	.002	41	view →
MESO	DFS	Quartile	III,IV	0.240	0.588	.004	36	view →
LIHC	OS	Median	All	0.716	0.844	.003	29	view →
STAD	DFS	Median	IV	0.166	0.508	.030	16	view →
ESCA	OS	Tertile	All	1.000	0.563	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ATP8B2–UVM (DFS)

Open the UVM breakdown →