ATP8B2

Across TCGA cell cohorts, ATP8B2 mutation is significantly associated with the RNA expression of many other genes, with 307 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8B2-associated genes across cancer lineages are DEFB108B, OR10K1, and OBP2B. Each is linked with ATP8B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8B2-to-partner and partner-to-ATP8B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB108B grouped by ATP8B2-low versus ATP8B2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B2→partner) and Y-score (partner→ATP8B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DEFB108B →	+0.046	+5.169	<.001	.004	3	2
STOMACH	OR10K1 →	+0.005	+4.285	<.001	.007	3	2
BONE	OBP2B →	+0.123	+5.169	<.001	.004	3	1
BONE	KRTAP22-2 →	+0.290	+5.169	<.001	.004	3	1
BONE	MROH5 →	+0.006	+5.169	<.001	.004	3	1
BLOOD_Myeloma	CDRT15L2 →	+0.020	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 307 associations by consensus.

DEFB108B by ATP8B2 expression — BONE

Explore this box plot interactively →