ATP8B1

Across TCGA patient cohorts, ATP8B1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8B1-associated genes across cancer lineages are c-Kit, p38-MAPK_pT180_Y182, and TFRC. Each is linked with ATP8B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP8B1-to-partner and partner-to-ATP8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by ATP8B1-low versus ATP8B1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B1→partner) and Y-score (partner→ATP8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.611	-3.169	.043	.017	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.274	-1.112	.044	.033	3	3
UCEC	TFRC →	+0.601	+1.999	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.250	-1.754	<.001	.001	3	2
UCEC	INPP4B →	-0.276	-2.999	.004	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.181	-2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

c-Kit by ATP8B1 expression — SKCM

Explore this box plot interactively →