ATP8B1

Across TCGA pan-cancer cohorts, ATP8B1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ATP8B1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATP8B1 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP8B1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where ATP8B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP8B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.992	<.001	12	view →
KIRC	Male	IV	−1.429	<.001	11	view →
LIHC	Female	II,III,IV	+1.586	<.001	8	view →
KICH	All	II,III,IV	−1.310	<.001	8	view →
THCA	Male	All	−0.911	<.001	8	view →
KIRP	Male	II,III,IV	−1.181	<.001	7	view →
BRCA	All	III,IV	+1.113	<.001	6	view →
READ	All	All	−1.662	<.001	5	view →
LUSC	All	All	+0.837	<.001	5	view →
LUAD	All	All	+0.500	<.001	5	view →
CHOL	Male	All	+1.906	<.001	3	view →
STAD	Male	All	+0.940	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ATP8B1–COAD

Open the COAD breakdown →