ATP8B1

Across TCGA cell cohorts, ATP8B1 mutation is significantly associated with the RNA expression of many other genes, with 1,689 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8B1-associated genes across cancer lineages are GPR33, PCARE, and ZNF391. Each is linked with ATP8B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP8B1-to-partner and partner-to-ATP8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR33 grouped by ATP8B1-low versus ATP8B1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B1→partner) and Y-score (partner→ATP8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPR33 →	+0.021	+2.959	<.001	.004	3	2
LUNG_NSCLC_LUAD	PCARE →	+0.022	+3.343	<.001	.005	3	2
LARGE_INTESTINE	ZNF391 →	+1.052	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	DIP2A →	+0.518	+3.082	.003	.007	3	2
LARGE_INTESTINE	HESX1 →	+0.548	+3.321	<.001	.003	3	2
LARGE_INTESTINE	DRICH1 →	+0.214	+2.588	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,689 associations by consensus.

GPR33 by ATP8B1 expression — STOMACH

Explore this box plot interactively →