ATP8B1

Across TCGA cell cohorts, ATP8B1 mutation is significantly associated with the mutation status of many other genes, with 3,389 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP8B1-associated genes across cancer lineages are MORC4, MAN2A1, and MYO5A. Each is linked with ATP8B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ATP8B1-to-partner and partner-to-ATP8B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MORC4 grouped by ATP8B1-low versus ATP8B1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8B1→partner) and Y-score (partner→ATP8B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MORC4 →	+3.240	+4.467	.004	.004	1	5
LARGE_INTESTINE	MAN2A1 →	+2.340	+3.252	<.001	<.001	1	5
STOMACH	MYO5A →	+4.025	+2.942	.009	.009	1	5
LARGE_INTESTINE	FER1L6 →	+2.050	+2.050	.003	.003	1	5
BLOOD_Lymphoma	RNF165 →	+5.584	+5.014	.003	.003	1	4
OVARY	FCHSD1 →	+4.977	+4.415	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,389 associations by consensus.

MORC4 by ATP8B1 expression — OVARY

Explore this box plot interactively →