ATP8A1

Across TCGA pan-cancer cohorts, ATP8A1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ATP8A1 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher ATP8A1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP8A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

ESCA, UCEC, and LUSC are the cancer types where ATP8A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.125	0.509	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.941	0.426	.005	32	view →
LUSC	DFS	Median	III,IV	0.234	0.647	.001	23	view →
BLCA	OS	Median	II,III,IV	1.000	0.414	.036	14	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.617	0.886	.038	6	view →
SKCM	OS	Median	III,IV	0.394	0.730	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ATP8A1–ESCA (DFS)

Open the ESCA breakdown →