ATP8A1

Across TCGA pan-cancer cohorts, ATP8A1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ATP8A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ATP8A1 RNA is repressed in tumor relative to normal tissue. In most cancer types ATP8A1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and LUAD are the cancer types where ATP8A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP8A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.790	<.001	12	view →
LUSC	Female	II,III,IV	−2.951	<.001	9	view →
LUAD	Female	II,III,IV	−1.866	<.001	9	view →
THCA	All	II,III,IV	−0.902	<.001	8	view →
HNSC	Male	All	−0.852	<.001	8	view →
UCEC	All	All	−1.088	<.001	6	view →
BLCA	Male	All	−0.925	.001	6	view →
BRCA	All	All	−0.750	<.001	6	view →
LIHC	All	All	+0.292	.005	6	view →
READ	All	II,III,IV	−1.620	.001	4	view →
KICH	All	All	+0.672	.010	3	view →
PRAD	All	All	+0.725	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ATP8A1–COAD

Open the COAD breakdown →