ATP8A1

Across TCGA pan-cancer cohorts, ATP8A1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATP8A1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ATP8A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP8A1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where ATP8A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.829	0.997	.001	16	view →
PDAC	DFS	Tertile	III,IV	0.974	0.370	.001	13	view →
CCRCC	DFS	Tertile	All	0.898	0.630	.009	12	view →
UCEC	DFS	Median	All	0.833	0.950	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATP8A1–LUAD (DFS)

Open the LUAD breakdown →