ATP8A1

Across TCGA patient cohorts, ATP8A1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP8A1-associated genes across cancer lineages are GAPDH, Rictor_pT1135, and Bcl-2. Each is linked with ATP8A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP8A1-to-partner and partner-to-ATP8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ATP8A1-low versus ATP8A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8A1→partner) and Y-score (partner→ATP8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.357	+2.087	.018	.004	3	3
STAD	Rictor_pT1135 →	-0.174	-3.000	.028	.036	3	2
STAD	Bcl-2 →	-0.238	-3.000	.040	.036	3	2
UCEC	eIF4E →	+0.126	+1.736	.033	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.111	-1.392	.019	.017	3	2
UCEC	JNK2 →	+0.260	+2.044	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

GAPDH by ATP8A1 expression — UCEC

Explore this box plot interactively →