ATP8A1

Across TCGA cell cohorts, ATP8A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,366 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ATP8A1-associated GO terms across cancer lineages are Regulation of hemostasis, Positive regulation of extrinsic apoptotic signaling pathway, and Regulation of coagulation. Each is linked with ATP8A1 in more than 10 cancer types. Because this analysis shows association rather than direction, both ATP8A1-to-partner and partner-to-ATP8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hemostasis grouped by ATP8A1-low versus ATP8A1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP8A1→partner) and Y-score (partner→ATP8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of hemostasis →	-0.214	-2.397	<.001	<.001	3	10
BREAST	Positive regulation of extrinsic apoptotic signaling pathway →	-0.096	-1.498	<.001	<.001	3	10
STOMACH	Regulation of coagulation →	-0.179	-1.971	<.001	<.001	3	10
BREAST	Positive regulation of sphingolipid biosynthetic process →	+0.102	+1.057	<.001	.003	3	9
LUNG_SCLC	Regulation of glutamate uptake involved in transmission of nerve impulse →	-0.197	-2.065	<.001	<.001	3	9
BREAST	Positive regulation of ceramide biosynthetic process →	+0.102	+1.057	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,366 associations by consensus.

Regulation of hemostasis by ATP8A1 expression — BREAST

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