ATP7A

Across TCGA patient cohorts, ATP7A mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP7A-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and GAPDH. Each is linked with ATP7A in more than 3 cancer types. Because this analysis shows association rather than direction, both ATP7A-to-partner and partner-to-ATP7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ATP7A-low versus ATP7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP7A→partner) and Y-score (partner→ATP7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.443	+1.663	.002	.001	3	4
UCEC	eIF4E →	+0.115	+1.293	.030	.031	3	3
UCEC	GAPDH →	+0.335	+1.353	.012	.013	3	3
UCEC	STAT3_pY705 →	-0.283	-1.295	<.001	.006	3	3
UCEC	TIGAR →	+0.111	+1.367	.003	<.001	3	3
UCEC	ATM →	-0.343	-1.638	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by ATP7A expression — UCEC

Explore this box plot interactively →