ATP7A

Across TCGA pan-cancer cohorts, ATP7A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ATP7A data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher ATP7A RNA is associated with better overall survival. In most high-consensus cancer types, elevated ATP7A expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

MESO, KIRC, and LGG are the cancer types where ATP7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.508	0.286	.001	98	view →
KIRC	OS	Tertile	All	0.750	0.541	<.001	89	view →
LGG	OS	Median	All	0.369	0.534	<.001	39	view →
ACC	DFS	Tertile	III,IV	0.468	0.087	.006	35	view →
KIRP	OS	Quartile	All	0.860	0.966	.004	35	view →
LIHC	DFS	Median	All	0.476	0.603	.001	28	view →
HNSC	OS	Tertile	All	0.233	0.543	.003	19	view →
UCS	DFS	Median	IV	0.885	0.440	.015	18	view →
THYM	DFS	Median	III,IV	1.000	0.463	.007	17	view →
STAD	DFS	Median	II,III,IV	0.468	0.601	.027	12	view →
SARC	OS	Quartile	All	0.374	0.784	.002	12	view →
SCLC	OS	Quartile	III,IV	0.549	0.146	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ATP7A–MESO (OS)

Open the MESO breakdown →