ATP7A

Across TCGA cell cohorts, ATP7A mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ATP7A-associated genes across cancer lineages are OR1L3, OR2M4, and PAX7. Each is linked with ATP7A in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP7A-to-partner and partner-to-ATP7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by ATP7A-low versus ATP7A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP7A→partner) and Y-score (partner→ATP7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	3
OVARY	OR2M4 →	+0.062	+3.700	<.001	.005	3	2
BLOOD_Leukemia	PAX7 →	+0.051	+4.137	<.001	.003	3	2
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1
SKIN	H2BW2 →	+0.092	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

OR1L3 by ATP7A expression — SKIN

Explore this box plot interactively →