ATP6V1H

Across TCGA pan-cancer cohorts, ATP6V1H RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ATP6V1H data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP6V1H RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP6V1H expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRC show a favorable association.

UVM, MESO, and LIHC are the cancer types where ATP6V1H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.256	0.841	<.001	103	view →
MESO	OS	Median	All	0.506	0.291	.002	68	view →
LIHC	OS	Median	All	0.378	0.651	<.001	56	view →
KIRC	DFS	Tertile	All	0.723	0.511	<.001	54	view →
DLBC	OS	Tertile	III,IV	0.797	0.154	.008	32	view →
COAD	DFS	Quartile	III,IV	0.462	0.747	.008	31	view →
BRCA	OS	Tertile	All	0.946	0.976	.001	30	view →
HNSC	DFS	Quartile	III,IV	0.607	0.740	.012	22	view →
LUSC	DFS	Quartile	III,IV	0.525	0.808	.006	19	view →
LAML	DFS	Quartile	All	0.454	0.687	.005	18	view →
CHOL	OS	Median	II,III,IV	0.915	0.362	.002	15	view →
PAAD	OS	Median	II,III,IV	0.322	0.578	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ATP6V1H–UVM (DFS)

Open the UVM breakdown →