Across TCGA pan-cancer cohorts, ATP6V1G2-DDX39B RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ATP6V1G2-DDX39B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where ATP6V1G2-DDX39B RNA is repressed in tumor relative to normal tissue. In most cancer types ATP6V1G2-DDX39B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and LUAD are the cancer types where ATP6V1G2-DDX39B tumor–normal differential expression is most reproducible.