ATP6V1C2

Across TCGA patient cohorts, ATP6V1C2 mutation is significantly associated with the RNA expression of many other genes, with 2,595 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1C2-associated genes across cancer lineages are ZNHIT3, TAF9, and NOL12. Each is linked with ATP6V1C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1C2-to-partner and partner-to-ATP6V1C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by ATP6V1C2-low versus ATP6V1C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1C2→partner) and Y-score (partner→ATP6V1C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.444	+2.399	<.001	<.001	3	2
UCEC	TAF9 →	+0.769	+2.378	<.001	<.001	3	2
UCEC	NOL12 →	+0.337	+2.091	<.001	<.001	3	2
PRAD	MTND4LP19 →	+0.294	+6.593	<.001	.001	3	2
UCEC	PTS →	+0.352	+2.016	.001	.001	3	2
SKCM	CENPH →	+0.732	+3.478	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,595 associations by consensus.

ZNHIT3 by ATP6V1C2 expression — UCEC

Explore this box plot interactively →