ATP6V1C2

Across TCGA patient cohorts, ATP6V1C2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1C2-associated genes across cancer lineages are JNK_pT183_Y185, p27_pT198, and p53. Each is linked with ATP6V1C2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ATP6V1C2-to-partner and partner-to-ATP6V1C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ATP6V1C2-low versus ATP6V1C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1C2→partner) and Y-score (partner→ATP6V1C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.140	-1.906	.013	.015	3	3
UCEC	p27_pT198 →	+0.080	+2.459	.025	.018	3	2
UCEC	p53 →	-0.301	-2.459	.020	.018	3	2
UCEC	Tuberin_pT1462 →	+0.229	+1.594	.003	.010	3	2
UCEC	eEF2 →	+0.296	+2.584	.013	.010	3	1
UCEC	EGFR_pY1068 →	-0.221	-1.584	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

JNK_pT183_Y185 by ATP6V1C2 expression — UCEC

Explore this box plot interactively →