ATP6V1C2

Across TCGA cell cohorts, ATP6V1C2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,272 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ATP6V1C2-associated GO terms across cancer lineages are Establishment of epithelial cell apical/basal polarity, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with ATP6V1C2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ATP6V1C2-to-partner and partner-to-ATP6V1C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of epithelial cell apical/basal polarity grouped by ATP6V1C2-low versus ATP6V1C2-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1C2→partner) and Y-score (partner→ATP6V1C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Establishment of epithelial cell apical/basal polarity →	-0.184	-0.974	<.001	<.001	3	9
LUNG_SCLC	Symbiont-mediated disruption of host cellular anatomical structure →	+0.109	+1.122	.002	.002	3	8
LUNG_SCLC	Symbiont-mediated disruption of host anatomical structure →	+0.109	+1.122	.002	.002	3	8
SOFT_TISSUE	DNA-templated DNA replication maintenance of fidelity →	+0.079	+0.260	<.001	.004	3	8
LUNG_SCLC	Regulation of centrosome cycle →	+0.090	+1.496	<.001	<.001	3	8
LUNG_SCLC	Regulation of centrosome duplication →	+0.098	+1.461	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,272 associations by consensus.

Establishment of epithelial cell apical/basal polarity by ATP6V1C2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →