ATP6V1C1

Across TCGA cell cohorts, ATP6V1C1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ATP6V1C1-associated genes across cancer lineages are OR2C1, OR10W1, and ACSM6. Each is linked with ATP6V1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1C1-to-partner and partner-to-ATP6V1C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by ATP6V1C1-low versus ATP6V1C1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1C1→partner) and Y-score (partner→ATP6V1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.078	+3.648	.008	.002	3	1
LARGE_INTESTINE	OR10W1 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.020	+3.000	<.001	.005	3	1
LARGE_INTESTINE	IQCF6 →	+0.181	+2.882	<.001	.005	3	1
LUNG_NSCLC_LUAD	MAGEB4 →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.043	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR2C1 by ATP6V1C1 expression — LARGE_INTESTINE

Explore this box plot interactively →