ATP6V1A

Across TCGA patient cohorts, ATP6V1A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V1A-associated genes across cancer lineages are PDCD4, PKC-delta_pS664, and EGFR_pY1068. Each is linked with ATP6V1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V1A-to-partner and partner-to-ATP6V1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ATP6V1A-low versus ATP6V1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1A→partner) and Y-score (partner→ATP6V1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.557	-2.169	.001	.003	3	2
UCEC	PKC-delta_pS664 →	-0.090	-1.415	.046	.046	3	2
UCEC	EGFR_pY1068 →	-0.278	-2.662	.003	<.001	3	1
UCEC	eIF4E →	+0.231	+2.169	.003	.003	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.321	.009	.034	3	1
UCEC	Fibronectin →	-0.273	-2.449	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by ATP6V1A expression — UCEC

Explore this box plot interactively →