ATP6V1A

Across TCGA cell cohorts, ATP6V1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,475 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ATP6V1A-associated GO terms across cancer lineages are Golgi lumen acidification, Synaptic vesicle lumen acidification, and Synaptic vesicle maturation. Each is linked with ATP6V1A in more than 17 cancer types. Because this analysis shows association rather than direction, both ATP6V1A-to-partner and partner-to-ATP6V1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi lumen acidification grouped by ATP6V1A-low versus ATP6V1A-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V1A→partner) and Y-score (partner→ATP6V1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Golgi lumen acidification →	+0.147	+1.034	<.001	<.001	3	18
SOFT_TISSUE	Synaptic vesicle lumen acidification →	+0.144	+0.933	<.001	<.001	3	18
KIDNEY	Synaptic vesicle maturation →	+0.143	+1.172	<.001	<.001	3	17
LUNG_SCLC	Endosomal lumen acidification →	+0.147	+0.844	<.001	<.001	3	17
BREAST	Lysosomal lumen acidification →	+0.136	+0.810	<.001	<.001	3	13
STOMACH	Process utilizing autophagic mechanism →	+0.075	+0.799	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,475 associations by consensus.

Golgi lumen acidification by ATP6V1A expression — KIDNEY

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