ATP6V0B

Across TCGA patient cohorts, ATP6V0B mutation is significantly associated with the RNA expression of many other genes, with 435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V0B-associated genes across cancer lineages are EMC7, LETM1, and ELAC2. Each is linked with ATP6V0B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V0B-to-partner and partner-to-ATP6V0B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC7 grouped by ATP6V0B-low versus ATP6V0B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V0B→partner) and Y-score (partner→ATP6V0B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMC7 →	+0.618	+3.617	<.001	.001	3	2
UCEC	LETM1 →	+0.551	+3.475	.001	.002	3	2
UCEC	ELAC2 →	+0.521	+3.210	.001	.009	3	2
BLCA	RN7SL447P →	+0.191	+4.497	<.001	.009	3	2
UCEC	PSAT1P4 →	+0.150	+2.733	.005	<.001	3	2
BLCA	MIR8059 →	+0.651	+7.892	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 435 associations by consensus.

EMC7 by ATP6V0B expression — UCEC

Explore this box plot interactively →