ATP6V0B

Across TCGA pan-cancer cohorts, ATP6V0B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP6V0B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ATP6V0B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP6V0B is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

BLCA, KIRC, and HNSC are the cancer types where ATP6V0B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP6V0B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+1.032	<.001	11	view →
KIRC	Male	II,III,IV	−0.825	<.001	11	view →
HNSC	Male	III,IV	+0.687	<.001	10	view →
LIHC	Female	II,III,IV	+1.268	<.001	9	view →
BRCA	All	III,IV	+1.353	<.001	8	view →
STAD	Female	All	+1.117	<.001	7	view →
KIRP	Male	All	−0.649	<.001	7	view →
UCEC	All	III,IV	+1.517	<.001	6	view →
COAD	Female	II,III,IV	+0.790	<.001	5	view →
CHOL	Male	All	+1.843	<.001	4	view →
ESCA	All	All	+0.672	<.001	4	view →
PRAD	All	All	+0.327	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP6V0B–BLCA

Open the BLCA breakdown →