ATP6V0B

Across TCGA patient cohorts, ATP6V0B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP6V0B-associated genes across cancer lineages are MEK1, Notch1, and P-Cadherin. Each is linked with ATP6V0B in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP6V0B-to-partner and partner-to-ATP6V0B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ATP6V0B-low versus ATP6V0B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP6V0B→partner) and Y-score (partner→ATP6V0B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.477	+3.459	.009	.005	3	2
COAD	Notch1 →	+0.217	+2.815	.033	.036	3	1
COAD	P-Cadherin →	+0.217	+2.832	.022	.035	3	1
COAD	ASNS →	+0.777	+2.815	<.001	.036	3	1
UCEC	MSH2 →	-0.313	-2.973	.006	.035	3	1
UCEC	S6_pS240_S244 →	+0.484	+3.459	.017	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by ATP6V0B expression — UCEC

Explore this box plot interactively →