ATP6V0A4

Across TCGA pan-cancer cohorts, ATP6V0A4 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ATP6V0A4 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ATP6V0A4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ATP6V0A4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, UCEC, and LIHC are the cancer types where ATP6V0A4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.116	0.706	<.001	39	view →
UCEC	DFS	Median	All	0.964	0.626	.017	24	view →
LIHC	OS	Median	II,III,IV	0.195	0.715	.009	12	view →
SKCM	DFS	Median	II,III,IV	0.877	0.672	.014	11	view →
COAD	DFS	Median	All	0.502	0.788	.004	10	view →
SCLC	DFS	Median	All	0.164	0.573	.009	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
KICH	DFS	Median	All	0.425	0.847	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ATP6V0A4–ACC (OS)

Open the ACC breakdown →