ATP6V0A4

Across TCGA pan-cancer cohorts, ATP6V0A4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATP6V0A4 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ATP6V0A4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ATP6V0A4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where ATP6V0A4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.753	0.453	.014	9	view →
LSCC	DFS	Tertile	III,IV	0.419	0.970	.049	4	view →
HNSC	DFS	Median	All	0.847	0.690	.025	2	view →
LUAD	DFS	Quartile	All	0.359	0.794	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATP6V0A4–CCRCC (DFS)

Open the CCRCC breakdown →