ATP5PB

Across TCGA patient cohorts, ATP5PB mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5PB-associated genes across cancer lineages are DUX4L8, OR2J3, and SETP15. Each is linked with ATP5PB in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5PB-to-partner and partner-to-ATP5PB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUX4L8 grouped by ATP5PB-low versus ATP5PB-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5PB→partner) and Y-score (partner→ATP5PB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DUX4L8 →	+0.013	+7.057	<.001	.009	3	2
SKCM	OR2J3 →	+0.042	+5.199	<.001	.003	3	2
UCEC	SETP15 →	+0.238	+3.484	.001	.004	3	2
UCEC	PRPS1P1 →	+0.101	+3.131	.005	.003	3	2
UCEC	IGHV1OR21-1 →	+0.769	+3.800	.005	.001	3	1
CESC	LINC02740 →	+0.082	+4.969	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

DUX4L8 by ATP5PB expression — BRCA

Explore this box plot interactively →