ATP5ME

Across TCGA pan-cancer cohorts, ATP5ME mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ATP5ME’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATP5ME mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ATP5ME is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and COAD are the cancer types where ATP5ME tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5ME mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.808	<.001	11	view →
CCRCC	Female	II,III,IV	−0.589	<.001	11	view →
COAD	Male	All	−0.345	<.001	10	view →
PDAC	All	All	−0.330	<.001	4	view →
LUAD	Male	All	−0.137	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ATP5ME–HNSC

Open the HNSC breakdown →