ATP5ME

Across TCGA pan-cancer cohorts, ATP5ME RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ATP5ME data layer compared with 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ATP5ME RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5ME expression acts as an unfavorable survival marker, although some lineages such as READ and THCA show a favorable association.

UVM, LUAD, and HNSC are the cancer types where ATP5ME RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.551	0.898	<.001	146	view →
LUAD	DFS	Quartile	III,IV	0.199	0.871	<.001	37	view →
HNSC	DFS	Tertile	II,III,IV	0.596	0.747	.002	35	view →
UCS	OS	Median	IV	0.404	0.752	.013	30	view →
KIRC	DFS	Quartile	III,IV	0.504	0.850	.004	28	view →
KICH	DFS	Quartile	All	0.673	1.000	.015	27	view →
ESCA	DFS	Quartile	III,IV	0.304	0.622	.006	19	view →
LGG	DFS	Quartile	All	0.698	0.846	.005	18	view →
PRAD	DFS	Tertile	All	0.664	0.909	<.001	18	view →
SCLC	DFS	Quartile	II,III,IV	0.201	0.598	.018	14	view →
READ	DFS	Quartile	II,III,IV	0.761	0.413	.028	11	view →
THCA	DFS	Quartile	All	0.869	0.724	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ATP5ME–UVM (DFS)

Open the UVM breakdown →