ATP5MC1

Across TCGA pan-cancer cohorts, ATP5MC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ATP5MC1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ATP5MC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5MC1 expression acts as an unfavorable survival marker.

KIRP, HNSC, and SCLC are the cancer types where ATP5MC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.088	0.920	<.001	48	view →
HNSC	DFS	Median	All	0.122	0.710	.001	24	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ATP5MC1–KIRP (DFS)

Open the KIRP breakdown →