ATP5MC1

Across TCGA pan-cancer cohorts, ATP5MC1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ATP5MC1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ATP5MC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP5MC1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LIHC, LUSC, and KICH are the cancer types where ATP5MC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5MC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+1.124	<.001	9	view →
LUSC	Male	All	+0.984	<.001	8	view →
KICH	All	II,III,IV	−0.817	<.001	7	view →
KIRC	Male	All	−0.634	<.001	7	view →
THCA	All	All	−0.368	<.001	7	view →
BRCA	All	III,IV	+0.841	<.001	6	view →
UCEC	All	All	+0.576	<.001	6	view →
LUAD	All	All	+0.478	<.001	5	view →
BLCA	All	All	+0.383	.043	2	view →
BRCA	All	IV	−0.344	.013	2	view →
COAD	All	All	−0.226	.031	2	view →
CHOL	All	All	+0.613	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ATP5MC1–LIHC

Open the LIHC breakdown →