ATP5MC1

Across TCGA patient cohorts, ATP5MC1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ATP5MC1-associated genes across cancer lineages are RNU6-365P, MIR1263, and MIR1283-1. Each is linked with ATP5MC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ATP5MC1-to-partner and partner-to-ATP5MC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-365P grouped by ATP5MC1-low versus ATP5MC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ATP5MC1→partner) and Y-score (partner→ATP5MC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-365P →	+0.229	+7.640	<.001	.009	3	1
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	1
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

RNU6-365P by ATP5MC1 expression — BLCA

Explore this box plot interactively →