ATP5F1E

Across TCGA pan-cancer cohorts, ATP5F1E RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ATP5F1E data layer compared with 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ATP5F1E RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ATP5F1E expression acts as an unfavorable survival marker, although some lineages such as OV and SKCM show a favorable association.

HNSC, ACC, and UVM are the cancer types where ATP5F1E RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.626	0.761	<.001	120	view →
ACC	DFS	Median	All	0.275	0.627	<.001	108	view →
UVM	DFS	Median	III,IV	0.244	0.724	<.001	105	view →
KIRC	OS	Tertile	All	0.819	0.919	<.001	96	view →
KICH	DFS	Median	II,III,IV	0.550	1.000	.002	69	view →
SCLC	DFS	Median	III,IV	0.362	0.699	.002	54	view →
LIHC	OS	Median	III,IV	0.318	0.706	<.001	51	view →
LAML	DFS	Median	All	0.404	0.697	<.001	48	view →
LGG	DFS	Median	All	0.671	0.800	<.001	40	view →
PRAD	DFS	Tertile	All	0.683	0.935	<.001	18	view →
DLBC	OS	Median	II,III,IV	0.299	1.000	.010	16	view →
UCS	DFS	Tertile	IV	0.381	0.956	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ATP5F1E–HNSC (DFS)

Open the HNSC breakdown →