ATP5F1E

Across TCGA pan-cancer cohorts, ATP5F1E RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ATP5F1E’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ATP5F1E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ATP5F1E is over-expressed in tumor.

HNSC, LIHC, and BRCA are the cancer types where ATP5F1E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ATP5F1E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.543	<.001	9	view →
LIHC	Female	II,III,IV	+1.089	<.001	8	view →
BRCA	All	III,IV	+0.670	<.001	6	view →
UCEC	All	All	+0.490	.003	6	view →
COAD	Female	II,III,IV	+0.422	<.001	5	view →
BLCA	All	All	+0.308	.008	5	view →
STAD	All	All	+0.436	.002	4	view →
LUAD	Female	All	+0.371	<.001	4	view →
CHOL	Male	All	+1.528	<.001	3	view →
ESCA	All	All	+0.686	.009	2	view →
READ	All	III,IV	+0.605	.020	2	view →
KIRP	All	All	+0.255	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ATP5F1E–HNSC

Open the HNSC breakdown →